Late-onset, hospital-acquired infections with MDR organisms are therefore frequent occurrences and outbreaks in neonatal wards in these settings have the potential to cause very high mortality and morbidity rates 4,5. This is often due to limited health budgets, particularly with regards to infection prevention and control resources. It is well documented that the burden of neonatal infections, and those that are antimicrobial-resistant, disproportionately affects low- and middle-income (LMIC) healthcare settings 1. Almost 50% of neonatal units prescribe WHO ‘reserve’ antibiotics as empirical therapy for neonatal sepsis. Uncontrolled antimicrobial prescribing drives AMR in many healthcare settings. have occurred frequently over the past decade. in Nepal 3 while in the major tertiary units in which we work in Sri Lanka and Indonesia, outbreaks due to ESBL-producing GNB and carbapenem-resistant Acinetobacter spp. Single-unit studies have revealed similarly high rates of third-generation cephalosporin resistance among Klebsiella spp. In neonatal units in South Africa and Bangladesh, two-thirds of GNB isolated from blood cultures were cephalosporin-resistant while 39% and 81%, respectively, were carbapenem-resistant 2. Recently, the NeoAMR network has also highlighted unexpectedly high rates of MDR Gram-negative bacterial (GNB) infections in infants across many continents 2. In India alone, almost 60,000 neonates die each year due to infections with MDR pathogens 1. The burden of drug resistance in neonatal sepsis In an era of increasing antimicrobial resistance (AMR), the burden of infections caused by multidrug-resistant (MDR) bacteria resistant to the current WHO empirical therapeutic guidelines is resulting in a persistently unacceptably high rate of perinatal and infant mortality globally. Infections in the neonatal period are one of the major contributors to an ongoing high rate of neonatal morbidity and mortality worldwide. While progress in reducing the rate of child mortality since the launch of the Millennium Development Goals in 1990 has been promising, improvements in reducing neonatal mortality have been far slower.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |